Additionally, in Prolia-treated men with nonmetastatic prostate cancer receiving ADT, a greater incidence of cataracts was observed. (Hint: it's not just. What should I know about Prolia vs. Boniva? If you have questions about this medicine, talk to your doctor, pharmacist, or health care provider. For example, if you have a serious UTI or other infection, call your doctor right away. Theyll likely suggest other treatment options for your condition. Some people using Prolia have developed bone loss in the jaw, also called osteonecrosis of the jaw. Coming to a Cleveland Clinic location?Hillcrest Cancer Center check-in changesCole Eye entrance closingVisitation and COVID-19 information, Notice of Intelligent Business Solutions data eventLearn more. Prolia and Forteo are both used to treat osteoporosis. Prolia is also used to treat glucocorticoid-induced osteoporosis in men and women at high risk of bone fracture. Certain kidney problems, such as chronic kidney failure, can cause a low calcium level in your blood. (2022). Prolia Healthline Media does not provide medical advice, diagnosis, or treatment. you can take. Yoga is an excellent way to manage symptoms of osteoporosis. They may also suggest exercises to help improve your bone strength and lower your risk for fractures and osteoporosis. Learn more about your health after menopause. If you develop hypocalcemia, your doctor will typically have you stop using Prolia. supplements Biosimilars usually cost less than brand-name drugs. Before starting Prolia treatment, talk with your doctor about any tooth procedures you have scheduled. Most side effects from Prolia are mild and can go away on their own within a few days or weeks. Prolia contains the active drug denosumab, while Tymlos contains the active drug abaloparatide. Mild side effects of Prolia that have been reported include: Mild side effects of many drugs may go away within a few days or a few weeks. Your doctor can check if you have osteoporosis, have low BMD, or have osteopenia by measuring your bone density. Prolia can also cause bones to not form correctly and reduced growth in a fetus. WebIn many individuals, calcium supplements are better absorbed when taken with food. For a basic overview of Prolia, including details about its uses, see this article. Keep out of the reach of children and pets. Prolia and Evenity are both biologic medications, but Prolia contains the active drug denosumab, while Evenity contains the active drug romosozumab-aqqg. But theyre each effective in treating osteoporosis and preventing bone loss. Available for Android and iOS devices. Serious side effects from Prolia can occur, but they arent common. It is given by a health care professional in a hospital or clinic setting. You may have questions about Prolia and your treatment plan. But weight gain may be a symptom of a side effect called peripheral edema. To see a side-by-side comparison of Prolia and Fosamax, view this drug article. These side effects include: Your risk for these serious side effects may be higher if youre older and have certain dental procedures. See additional information. Your doctor or pharmacist can tell you more about the potential side effects of Prolia and ways to reduce them. If youre able to become pregnant, your doctor will order a pregnancy test for you before you take Prolia. Xgeva is also used to treat giant cell tumor of the bone. Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. Pay special attention to your dental hygiene. If your pain doesnt ease with OTC options, your doctor may suggest prescription pain medication. Talk with your doctor about your health history and discuss your risks with Prolia treatment. In rare cases, your doctor may have you self-inject Prolia at home. Osteoporosis Medications (Bisphosphonates) - Johns Hopkins What are some frequently asked questions about Prolia? The two most common forms of arthritis are osteoarthritis and rheumatoid arthritis (RA). Prolia contains the active drug denosumab, and Reclast contains the active drug zoledronic acid. Learn strategies you can use today. Having a tooth extraction while youre using Prolia may increase your risk for these side effects. If you have serious side effects from Prolia, call your doctor right away. Because Prolia can also cause low blood calcium, your risk may increase if you receive Prolia. If the user is trying to grow bone due to osteoporosis, osteopenia, or any reason, the recommended intake is 4 capsules divided into 2 doses also taken in the morning and evening with food. But hair loss has been reported by people who have taken Prolia since then. You can learn more about how we ensure our content is accurate and current by reading our. In addition, your doctor will most likely recommend that you take calcium and vitamin D supplements while taking bisphosphonates, since vitamin D helps your body to absorb calcium. Use of the term male in this article refers to sex assigned at birth. If you have more questions about what to expect with dental procedures while youre taking Prolia, talk with your doctor or dentist. Prolia may not be right for you if you have certain medical conditions or other factors that affect your health. Use of the term female in this article refers to sex assigned at birth. They can suggest ways to help relieve these side effects. Prescribing Information and WebAdults ages 19 through 50 should not get more than 2,500 mg calcium total per day (including food and supplements). You might be interested in seeing how Prolia and the drug Boniva compare. But if the side effects last longer than that, bother you, or become severe, be sure to talk with your doctor or pharmacist. Learn about the highest quality calcium supplements here. Serious skin infections may occur, but are uncommon Prolia comes as a solution thats given as an injection under your skin. They can tell you more about benefits and risks of Prolia and Forteo. But Prolia is given once every 6 months by a healthcare professional. Your doctor may suggest limiting foods that are high in trans fats, such as fried foods. It may also be higher if you have dental work done while youre taking Prolia. You should also ask your doctor if Prolia is safe for you if you have or have had: Additionally, let your doctor know if youre pregnant or breastfeeding. If youve noticed hair loss since starting Prolia treatment, talk with your doctor. To learn more about this, see the How is Prolia administered? section below. If youve already gone through menopause, your risk for bone loss is increased. Prolia is an injection prescribed for certain adults with osteoporosis, which Calcium Supplements Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. They will also explain how much youll be given and how often. If you are a healthcare professional, click "I Agree" to continue. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. Prolia is a prescription medicine used to treat bone loss in men who are at high risk for fracture receiving certain treatments Use effective birth control while using denosumab and for at least 5 months after your last dose. Take good care of your teeth and gums while you receive Prolia. They can also happen if you have certain conditions or if you take certain medications. So be sure to talk with your doctor about any past or upcoming surgery before starting treatment with the drug. have low blood calcium; or are pregnant or plan to become pregnant, as Prolia may harm your unborn baby; or are allergic to denosumab or any ingredients in Prolia. This is the drugs mechanism of action. With low BMD your bone tissues have less mineral, which means they become weaker. Compared to other osteoporosis treatments, only Proliais1 shot every 6 months. (such as prednisone) for at least six months and are at high risk for fracture. But, in some cases, alcohol can affect your balance and increase your risk for falls. Before you receive Prolia, tell your doctor if you have kidney disease (or if you are on dialysis), a weak immune system, a history of hypoparathyroidism or thyroid surgery, a history of intestinal surgery, a condition that makes it hard for your body to absorb nutrients from food, or if you are allergic to latex. * For more information about this side effect, see Side effect specifics below. Prolia is also available in a biosimilar form. But unlike generics, which are made for nonbiologic drugs, biosimilars are made for biologic drugs.) Ask your doctor about your own risk. Not getting enough calcium in your diet can lead to fragile, brittle bones that are more prone to fractures and disease. kidney disease (or if you are on dialysis); a weak immune system (caused by disease or by using certain medicines); hypoparathyroidism (decreased functioning of the parathyroid glands); any condition that makes it hard for your body to absorb nutrients from food (malabsorption); if you are scheduled for a dental procedure; if you cannot take daily calcium and vitamin D; or. MEDICATION GUIDE Prolia (PR-lee-a) (denosumab) Visit www.fda.gov/medwatch, orcall1-800-FDA-1088. Some people may have an allergic reaction to Prolia. Prolia may lower the level of calcium in your blood. It is important to check supplement labels to ensure that the product meets United States Pharmacopeia (USP) standards. They may be able to help you identify the cause. For information about the difference between sex and gender, see this article. Nonmetastatic means the cancer hasnt spread to other areas of the body. Bring someone with you to your appointment if doing so will help you feel more comfortable. Common If youre concerned about tingling while using Prolia, talk with your doctor. Symptoms may include jaw pain, swelling, numbness, loose teeth, gum infection, or slow healing after injury or surgery involving the gums. Prolia is meant to be used in combination with calcium and vitamin D supplements. We do not endorse non-Cleveland Clinic products or services. They include bone pain, back pain, and a higher risk of certain infections. Call your doctor for medical advice about side effects. Mild side effects that have been reported with Prolia include: These side effects may be temporary, lasting a few days or weeks. Talk with your doctor if youd like to know about taking generic denosumab. And be sure to let your doctor know about all the medications youre currently taking. Tell your doctor about all other medicines you use. Talk with your doctor about which other treatments are better choices for you. If you receive Prolia, you should not receive XGEVA. Your risk for infection with Prolia may be higher if you have a weakened immune system. Xgeva is used to treat a high calcium level due to cancer and to prevent bone fractures and other bone problems caused by multiple myeloma or cancer bone metastases. You do not give Prolia to yourself. You may need to have a dental exam before you begin treatment with Prolia. Starting an osteoporosis drug? Here The Prolia is making my leg bones and jaw bones hurt. Last updated on Feb 8, 2023. Prolia and Xgeva both contain the active drug denosumab, but they are not approved to treat all of the same conditions. Other conditions associated with osteonecrosis of the jaw include blood clotting disorders, anemia (low red blood cells), and a pre-existing dental problem. You (A placebo is a treatment with no active drug.). A solid routine can help to strengthen your muscles and bones, which helps to lower your, If you have osteoporosis, diet plays a vital role in managing your condition. How Viagra became a new 'tool' for young men, Ankylosing Spondylitis Pain: Fact or Fiction, https://www.ada.org/en/member-center/oral-health-topics/osteoporosis-medications, https://www.accessdata.fda.gov/drugsatfda_docs/label/2022/125320s210lbl.pdf, New clues to slow aging? 8,432 people who take Prolia and Calcium together, and have interactions are studied. Your doctor should examine your mouth before you start Prolia and may tell you to see your dentist. Call your doctor for instructions if you miss a dose or miss an appointment for your Prolia injection. Prolia is a prescriptionmedicine used to treat bone loss in women who are at high risk for fracture receiving certain treatments for breast cancer that has not spread to other parts of the body. With medical big data and AI algorithms, eHealthMe is running millions of phase IV trials and makes the results available to the public. For more information on this side effect, see Side effect specifics below. Talk with your doctor about which medication is right for you. Over time, Prolia helps to improve the density and strength of your bones by slowing bone loss. Xgeva is another brand of denosumab that treats high calcium levels caused by cancer and prevents bone breaks. The phase IV clinical study analyzes what interactions people who take Prolia and Calcium have. Let your doctor know if you have questions about which drug is recommended for you. The most common side effects of Prolia in women being treated for osteoporosis after menopause are back pain, pain in your arms and legs, high cholesterol, muscle pain, and bladder infection. Prolia is a prescription medicine used to treat osteoporosis in women after menopause who are at high risk for fracture Prolia Allergic reaction. If you want to stop taking Prolia, tell your doctor. You should make sure you get enough calcium and vitamin D while you are taking this medicine, unless your doctor tells you not to. Bone density decreases with time, and some people have a risk of developing weak or brittle bones. Most Medicare plans and other insurance plans cover Prolia. Copyright 2023 Elsevier Inc. All Rights Reserved. Usually, but it depends. Please know that the sponsors of this site are not responsible for content on the site you are about to enter. They include: not getting enough calcium and vitamin D smoking drinking too much alcohol using certain medications, such as corticosteroids and anticonvulsants not getting enough weight-bearing exercise (at least 30 minutes on most days). If your pain is more severe, your doctor may suggest prescription pain medication or physical therapy. MNT is the registered trade mark of Healthline Media. This drug may not be the right treatment for your condition if you have certain medical conditions or other factors that affect your health. What should I know about Prolia vs. Reclast? But if you think youre having a medical emergency, call 911 or your local emergency number. They need to know if you have any of these conditions: This medicine is for injection under the skin. Heres a short list of some of the mild side effects that Prolia can cause. This may include acetaminophen (Tylenol), naproxen (Aleve), or ibuprofen (Advil, Motrin). Symptoms of a severe allergic reaction can include swelling under your skin, typically in your eyelids, lips, hands, or feet. Doing so will help you avoid the risk for a low calcium level during treatment. More than half of American adults take an herbal or dietary supplement, and many more use over-the-counter or prescription drugs to manage maladies ranging from the occasional headache to chronic health conditions or mood disorders.. For many, it is part of their daily routine. 2023 Healthline Media UK Ltd, Brighton, UK. Prolia works by blocking osteoclasts (certain bone cells) from breaking down bone tissue in your body. WebYour doctor may prescribe calcium and vitamin D to help prevent low calcium levels in Before you have any dental work done, tell your dentist you are receiving this medicine. Osteoporosis medications and medication-related osteonecrosis of the jaw. Coral calcium is also used in maxillofacial surgery and bone grafting. A few examples of bisphosphonates include: If youd like to know more about using a bisphosphonate for your condition, talk with your doctor. Prolia (denosumab) injection, for subcutaneous use. If the side effects seem life threatening or you think youre having a medical emergency, immediately call 911 or your local emergency number. Keep in mind that side effects of a drug can depend on: Additionally, you may experience different side effects from those listed below based on the condition youre treating with Prolia. Do not use denosumab if you are pregnant. For instance, if you have a health condition that causes excess calcium in Your doctor can also advise you on symptoms of low calcium to look for. Although both drugs are approved to treat similar conditions, they work in different ways. But if they become bothersome, talk with your doctor or pharmacist. Prolia - Patient Information Leaflet (PIL) - (emc) - medicines Call your doctor or health care professional if you are unable to keep an appointment. This medicine may be used for other purposes; ask your health care provider or pharmacist if you have questions. Be sure to talk with your doctor about your health history before you take Prolia. Before taking Prolia, tell your doctor about all of your medical conditions, including if you: Your healthcare provider should do a pregnancy test before you start treatment with Prolia. They may recommend ways to ease your symptoms and determine whether you should keep taking Prolia. Your FRAX score is your risk of having an osteoporosis-related fracture in the next 10 years. For more information about how Prolia and Zometa compare with each other, see this article. And in my mind, that's no different than scheduling a visit to the dentist twice a year. Prolia may lower the calcium levels in your blood. Prolia is injected under the skin. You should use an effective method of birth control (contraception) during treatment with Prolia and for at least 5 months after your last dose of Prolia. But they each work differently because Prolia is a monoclonal antibody (it may also be called a miscellaneous bone resorption agent) and Reclast is a bisphosphonate which means they have different side effects, other uses, tolerability, and effectiveness profiles. If youre concerned about hair loss with Prolia, talk with your doctor. This can cause your weight to change and may explain any weight gain since starting Prolia treatment. Prolia is a prescription medicine used to increase bone mass in men with osteoporosis who are at high risk for fracture. 12 Low serum calcium levels should be corrected before starting denosumab; supplemental calcium and vitamin D is required in patients predisposed to hypocalcaemia (see Ensure adequate calcium and vitamin D intake ). You will receive your Prolia injection from your healthcare provider at a their office or clinic. Sciatica was a less common side effect in females* who received Prolia for osteoporosis after menopause. High cholesterol itself doesnt cause any symptoms. Your doctor or pharmacist can tell you about any interactions these may cause with Prolia. All rights reserved. You might like to know how Prolia and the drug Evenity compare. This lowers your risk for bone fractures. According to the American Dental Association, your risk of this problem may increase if you receive denosumab (the active drug in Prolia) for longer than 2 years. Prolia can also cause low calcium levels. With medical big data and proven AI algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. Continue reading, While there are no known drug interactions between Prolia (generic name: denosumab) and alcohol, but you should check with your doctor first before you drink.

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