Fam. Sharma, A. et al. This report describes a rare case of a diffuse cutaneous allergic reaction to Dermabond following its use to close a surgical incision, its prompt identification, and treatment after presentation to an emergency department. This second exposure to Dermabond caused an intense contact dermatitis that readily resolved with steroid use. & Thode, H. C. Jr. A review of the literature on octylcyanoacrylate tissue adhesive. None of the patients received systemic steroid therapy or wound revision. Accessibility Healthline has strict sourcing guidelines and relies on peer-reviewed studies, academic research institutions, and medical associations. In this retrospective cohort study, we evaluated the incidence and characteristics of contact dermatitis (type IV hypersensitivity reaction) post application of Dermabond (Trade name PRINEO . Sachse MM, Junghans T, Rose C, Wagner G (2013) Allergic contact dermatitis caused by topical 2-octyl-cyanoacrylate. The https:// ensures that you are connecting to the Percutan Tech. Nunley, Julia redness or discoloration, or visible rash, skin blisters that may drain fluid (especially if you scratch at the rash), a rash that appears quickly, spreads, and covers all or most of your body, shortness of breath or difficulty breathing, antibiotics if your rash is caused by an infection, prescription anti-inflammatory medications, a replacement medication if your rash was caused by a drug allergy. Of the three excluded patients, one had scabies and two had dyshidrotic eczema. The .gov means its official. Unauthorized use of these marks is strictly prohibited. There has never been a reported case resulting from gynaecologic surgery until now. Manuscript. J. Surg. 2017;77(6):414-415. While your rash may resolve quickly, you may need to change bandages or medications your doctor has prescribed. Within six hours of receiving steroids, the erythema and pruritis were improved. Diffuse Cutaneous Allergic Reaction to Dermabond. The site is secure. Recently, we reported a 14 percent incidence of allergic reaction to the cyanoacrylate-based surgical glue Dermabond (Ethicon, Inc., Somerville, N.J.). 121 62 Y.H.P. 8600 Rockville Pike Before Learn the signs and symptoms of latex allergies and how you can limit, Sunspots, sometimes called liver spots, are very common. 0000010011 00000 n Jurado-Palomo J, Caballero T, Fernndez-Nieto M, Quirce S (2009) Occupational asthma caused by artificial cyanoacrylate fingernails. 17, 670672 (2010). However, in some patients, it mimics postoperative infection, causes severe local or systemic reactions, and eventually, cosmetic sequelae17. 0000040610 00000 n 0000017254 00000 n Occupational allergic contact dermatitis caused by photobonded sculptured nails and a review of (meth) acrylates in nail cosmetics. Provided by the Springer Nature SharedIt content-sharing initiative. These materials can irritate the skin or cause an allergic reaction in some people. What Causes White Spots to Form on Your Nipple? J. Adhes. Hysterectomy Recovery (post hysterectomy) . Rash After Surgery: Causes, Diagnosis, Treatment, and When to Worry Pamela L. Scheinman, Marc Vocanson, Ari M. Goldminz, Hyo-Eun Kwon, Hye-Jin Ahn, Min Kyung Shin, Stephan Weidinger, Lisa A. Beck, Alan D. Irvine, Young Jae Kim, Dong Jun Lim, Chong Hyun Won, Vasco Silva-Neves, Vitor Hugo, Miguel Pais-Vieira, Mario Mastrocola, Georg Matziolis, Henk Eijer, Julie Bruce, Blessing Oyedemi, Freya Harrison, Young-Je Kim, Mi Ji Choi, Beom Joon Kim, Raiyyan Aftab, Vikash H. Dodhia, Ryckie G. Wade, Scientific Reports Surgical wound closure by staples or sutures? A prospective, randomized controlled trial comparing n-butyl cyanoacrylate tissue adhesive (LiquiBand) with sutures for skin closure after laparoscopic general surgical procedures. Severe dermatitis from Dermabond (R) surgical glue RicciJA, ParekhNN, DesaiNS. and J.W.C. 0000009330 00000 n 2018 Gorski J. 0000062096 00000 n Key words Of note, the patient underwent a tubal ligation one year before this procedure. Pruritus will begin at the incision sites around post-operative day 3 and continue until development of visually apparent erythematous wheals surrounding each site around post-operative day 7. Figure 1. Tissue adhesives for closure of surgical incisions. She was unable to see the surgeon on that day. 2019. 0000013256 00000 n Adv. Peiser, M. et al. 43, 625627 (2006). 0000002088 00000 n Uncommonly, patients present with allergic reactions to the adhesive compounds; these allergies are often misdiagnosed as cellulitis or another infectious process, and are incorrectly treated. Allergy Clin. Parkerson, Jamie Can DERMABOND PRINEO System cause blistering? The incidence of ACD from the use of 2-octyl cyanoacrylate and n-butyl cyanoacrylate topical skin adhesives was 2.7% and 2.2%, respectively. Postoperative dressing was performed with povidone-iodine, which was also used for preoperative skin preparation, at intervals of 23days for up to 2weeks after surgery. Emerg. Epub 2020 Sep 3. Epub 2021 Dec 16. Strategic Goals and Yagnatovsky M, Pham H, Rokito A, Jazrawi L, Strauss E. Phys Sportsmed. ACD was considered as a dependent variable, while age, sex, body mass index, diabetes, smoking, asthma, history of atopic dermatitis, history of contact dermatitis, neutrophil count, eosinophil count, and anatomical region were considered as independent variables. The monomer polymerizes upon contact with the applicator tip, water, and exposure to body temperatures. Alotaibi, Nawaf Naif HysterSisters.com is a massive online community with over 475,000 members and over 5 million posts. Allergic contact dermatitis due to the liquid skin adhesive Dermabond Second, the patients in this study were confined to the application of topical skin adhesives to foot and ankle surgeries so that generalization of the results to the whole body can be questioned. J. Arthroplasty 28, 553556 (2013). Contact Dermatitis. Figure 2. Therefore, we believe that the presence or absence of a patch test would not have significantly affected the results of the study. Patients were followed up between the first and second week after surgery, and surgical wounds were inspected by orthopedic surgeons. Collaborations, Submit 7 status post total laparoscopic hysterectomy and bilateral salpingo-oophorectomy with sudden onset of erythema and pruritus around all four port site incisions (Figure 1). Published by John Wiley & Sons Ltd. We retrospectively reviewed 1145 patients (739 patients with 2-octyl cyanoacrylate and 406 patients with n-butyl cyanoacrylate) who underwent skin closure with topical skin adhesives. On postoperative day 13, itching began again laterally and her husband injected a single 40-mg dose of Depo-Medrol (Pfizer Inc., New York). The dermatologist diagnosed ACD based on history of exposure, morphology (well-demarcated pruritic eczematous eruptions, papules, or vesicles), and regional distribution (localized in the area of skin that was exposed to skin adhesives) (Fig. But a cold compress or cooling pack (applied on top of clothing, not directly against the skin) will give your itch a bit of extra relief. Aesthet Surg J. Subsequent dermatologic evaluation confirmed the suspicion of an allergic reaction to Dermabond. Pediatr Emerg Care. Care must be taken to treat the symptoms of the allergic reaction while maintaining the integrity of the surgical incisions. Longer-chained cyanoacrylates, such as the 2-octyl cyanoacrylate monomer present in Dermabond, releases less degradation products than the short-chained monomers thus producing less potential histotoxicity. and Did you have pelvic pain following your hysterectomy? PDF DERMABOND PRINEO Skin Closure Systems Discussion Guide Of the 1145 patients included in the study, 32 (2.8%) patients were referred to dermatologists for suspected ACD after the use of a topical skin adhesive in the foot and ankle surgery, and 29 (2.5%) patients were diagnosed with ACD. This report describes a rare case of a diffuse cutaneous allergic reaction to Dermabond following its use to close a surgical incision, its prompt identification, and treatment after presentation to an emergency department. PMC 39, 12831289 (2018). Thakkar, Punam G. 2018. %%EOF Spauwen, P. H., de Laat, W. A. This article describes a severe allergic reaction to Dermabond following breast augmentation/mastopexy. Keywords: Acad. Nakagawa, Shiho Clipboard, Search History, and several other advanced features are temporarily unavailable. Her itching ceased within hours of these final treatments. Dermatitis 25, 99100 (2014). Acad. Seven days postoperatively, the patient's sutures were removed without incident (Figure 2). Lefvre S, Valois A, Truchetet F (2016) Allergic contact dermatitis caused by Dermabond (). B, Two months after breast augmentation/mastopexy and resolution of her allergic reaction to Dermabond. official website and that any information you provide is encrypted Although cyanoacrylates traditionally have been associated with low rates of sensitization, allergic contact dermatitis (ACD) to Dermabond products is being increasingly reported after orthopedic surgery. Lee, Esther An infectious disease specialist was consulted. 2021. Objective: Ethicon Inc. (2011) Dermabond Advanced - Topical Skin Adhesive: Instructions for Use, San Lorenzo, Puerto Rico. 69, 763781 (2012). Acad. If a superficial wound infection was suspected, oral antibiotics were administered. Hysterectomy Defined Hysterectomy Facts Laparoscopic Hysterectomy Vaginal Hysterectomy Abdominal Hysterectomy Robotic . Diffuse Cutaneous Allergic Reaction to Dermabond, Division of Plastic Surgery, Brigham and Women's Hospital, Harvard Medical School, Boston, MassachusettsUSA, Department of Physical Medicine and Rehabilitation, Thomas Jefferson University Hospital, Philadelphia, PennsylvaniaUSA, Department of Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, MassachusettsUSA, https://doi.org/10.1017/S1049023X14001010, Get access to the full version of this content by using one of the access options below. This report describes a rare case of a diffuse cutaneous allergic reaction to Dermabond following its use to close a surgical incision, its prompt identification, and treatment after presentation to an emergency department. HtV6}7Rno[o6HRvZJ\$*^${gg.`6{u~ujH`:vAUwK,7uXFqv?/#d3/~(8oVI#KG :8;+HjQ This site needs JavaScript to work properly. Cleft Palate Craniofac. PMC Unable to load your collection due to an error, Unable to load your delegates due to an error. doi: 10.3928/01477447-20200827-01. Wound closure with 2-octyl cyanoacrylate (Dermabond; Ethicon, Somerville, New Jersey USA) has recently increased in popularity across a wide spectrum of physicians ranging from surgeons to emergency medicine practitioners. "useRatesEcommerce": false 2-octyl cyanoacrylate should slough off naturally with desquamation of the epidermis 7-14 days after application [14]. The risk factors for ACD were identified using logistic regression analysis of odds ratios. 0000020617 00000 n Chen, Alex TREK-1 and TREK-2 knockout mice are not resistant to halothane or isoflurane. 2017 May;45(2):195-198. doi: 10.1080/00913847.2017.1283208. Clin. Prehosp Disaster Med. Close this message to accept cookies or find out how to manage your cookie settings. Hamilton, Canada. Register Clinical Trials, Guidelines for Care 20, 219223 (2004). This creates a functional glue when placed on the skin. 2014. After the surgical procedure of each patient, the fascia and subcutaneous layers were closed using 20 and 30 synthetic absorbable braided sutures. Your doctor should be notified of any symptoms of infection, so treatment can begin immediately. PubMedGoogle Scholar. This decline has been attributed to the introduction of minimally invasive techniques such as uterine artery embolization for the treatment of leiomyomata and non-surgical ablative therapies that are now commonly used for abnormal benign uterine bleeding [1]. Interv. ACD cases were treated using steroid ointment and oral antihistamines. The patient was advised to remove the skin adhesive with petroleum jelly and acetone. We use cookies to distinguish you from other users and to provide you with a better experience on our websites. publishing polices. Wound complications after 2-octyl skin closure systems for total joint arthroplasty. et al. A, Preoperative view of a 36-year-old woman. The material is rapidly converted from a liquid to a solid state via polymerization at room temperature without the need for a catalyst, evaporation of a solvent or application of pressure [5]. Rash 101 in adults: When to seek medical treatment. In the logistic regression analysis, age, sex, body mass index, diabetes, smoking, asthma, history of atopic dermatitis, history of contact dermatitis, neutrophil count, eosinophil count, and anatomical region did not show any correlation with the occurrence of allergic contact dermatitis (Table 2). In this case, antibiotics were continued because the vesicular reaction created open wounds near the silicone implants; secondary infection of the dermatitis would have resulted in loss of the implants. Wound closure with 2-octyl cyanoacrylate (Dermabond; Ethicon, Somerville, New Jersey USA) has recently increased in popularity across a wide spectrum of physicians ranging from surgeons to emergency medicine practitioners. Additional components of Dermabond include plasticizers that aid in the flexibility of the wound during the healing process, stabilizers to prolong the shelf life, and polymerization inhibitors to delay the transition of the product from liquid to solid.2 The polymer hydrolyzes in the body, creating formaldehyde, which causes inflammation. Cochrane Database Syst Rev. Please enable it to take advantage of the complete set of features! Diffuse Cutaneous Allergic Reaction to Dermabond Seo JH, Lee DH (2008) Patient satisfaction with a tissue adhesive in preauricular fistulectomy. It. Dermabond is not used on areas such as the eyes and mouth. All authors reviewed the manuscript. Contact Dermatitis. Search for other works by this author on: Allergic contact dermatitis after postsurgical repair with 2-octylcyanoacrylate, FDA summary memo: General and Plastic Surgery Devices Advisory Committee (Panel) Meeting, August 25, 2006, A prospective comparison of octyl-2-cyanoacrylate and suture in standardized facial wounds, Use of 2-octyl-cyanoacrylate skin adhesive (Dermabond) for wound closure following reduction mammaplasty: A prospective, randomized intervention study, Ectopic contact dermatitis from ethyl cyanoacrylate instant adhesives, Contact dermatitis to ethyl-cyanoacrylate-containing glue, 10 years of patch testing with the (meth)acrylate series, Foreign body reaction after usage of tissue adhesives for skin closure: A case report and review of the literature, 2009 American Society for Aesthetic Plastic Surgery, Ultrasound Calculation of Fat Volume for Liposuction: A Clinical Software Validation, Opioid Prescribing Patterns in Body Contouring Surgery, Perspectives on Cybersecurity and Plastic Surgery: A Survey of Plastic Surgeons and Scoping Review of the Literature, Alternative Abdominal Wall Plication Techniques: A Review of Current Literature, Repair of Congenitally Defective Type of Earlobe Clefts With Residual Lobular Tissue: A Convenient and Effective Surgical Technique, https://doi.org/10.1016/j.asj.2009.02.019, http://www.fda.gov/ohrms/dockets/ac/06/briefing/2006-4233b2_01.pdf, Receive exclusive offers and updates from Oxford Academic, Simultaneous Breast Augmentation and Mastopexy.

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